CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q13546
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q13546
RIPK1_HUMAN
Homo sapiens
Receptor-interacting serine/threonine-protein kinase 1

PDB Structure

PDB 6NW2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Potent and selective inhibitors of receptor-interacting protein kinase 1 that lack an aromatic back pocket group.
Hamilton, G.L., Chen, H., Deshmukh, G., Eigenbrot, C., Fong, R., Johnson, A., Kohli, P.B., Lupardus, P.J., Liederer, B.M., Ramaswamy, S., Wang, H., Wang, J., Xu, Z., Zhu, Y., Vucic, D., Patel, S.
Bioorg.Med.Chem.Lett.