CATH Domain 6nkpB00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.120	Jelly Rolls
	2.60.120.260	Galactose-binding domain-like

Domain Context

CATH Clusters

Superfamily	Galactose-binding domain-like
Functional Family	Ephrin type-A receptor 2

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P29317

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P29317

EPHA2_HUMAN

Homo sapiens

Ephrin type-A receptor 2

PDB Structure

PDB	6NKP
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling. Gomez-Soler, M., Petersen Gehring, M., Lechtenberg, B.C., Zapata-Mercado, E., Hristova, K., Pasquale, E.B. J.Biol.Chem.