CATH Domain 6mweB02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Tyrosine-protein kinase receptor Tie-1

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt Q02763

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q02763

TIE2_HUMAN

Homo sapiens

Angiopoietin-1 receptor

PDB Structure

PDB	6MWE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2 Harney, A.S., Karagiannis, G.S., Pignatelli, J., Smith, B.D., Kadioglu, E., Wise, S.C., Hood, M.M., Kaufman, M.D., Leary, C.B., Lu, W.P., Al-Ani, G., Chen, X., Entenberg, D., Oktay, M.H., Wang, Y., Chun, L., De Palma, M., Jones, J.G., Flynn, D.L., Condeelis, J.S. Mol. Cancer Ther.