CATH Classification

Domain Context

CATH Clusters

Superfamily Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family L-lactate dehydrogenase A chain

Enzyme Information

1.1.1.27
L-lactate dehydrogenase.
based on mapping to UniProt P00341
(S)-lactate + NAD(+) = pyruvate + NADH.
-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

UniProtKB Entries (1)

P00341
LDHA_SQUAC
Squalus acanthias
L-lactate dehydrogenase A chain

PDB Structure

PDB 6LDH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Refined crystal structure of dogfish M4 apo-lactate dehydrogenase.
Abad-Zapatero, C., Griffith, J.P., Sussman, J.L., Rossmann, M.G.
J.Mol.Biol.