CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.210 | Beta Polymerase; domain 3 |
|
3.30.210.10 | DNA polymerase, thumb domain |
Domain Context
CATH Clusters
| Superfamily | DNA polymerase, thumb domain |
| Functional Family | DNA-directed DNA/RNA polymerase mu |
Enzyme Information
| 2.7.7.7 |
DNA-directed DNA polymerase.
based on mapping to UniProt Q9NP87
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
|
UniProtKB Entries (1)
| Q9NP87 |
DPOLM_HUMAN
Homo sapiens
DNA-directed DNA/RNA polymerase mu
|
PDB Structure
| PDB | 6IPN |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions.
J.Am.Chem.Soc.
|