CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.1800 | DCoH-like |
|
3.90.1800.10 | RNA polymerase alpha subunit dimerisation domain |
Domain Context
CATH Clusters
| Superfamily | RNA polymerase alpha subunit dimerisation domain |
| Functional Family | DNA-directed RNA polymerase subunit beta |
Enzyme Information
| 2.7.7.6 |
DNA-directed RNA polymerase.
based on mapping to UniProt P22138
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.
|
UniProtKB Entries (1)
| P10964 |
RPA1_YEAST
Saccharomyces cerevisiae S288C
DNA-directed RNA polymerase I subunit RPA190
|
PDB Structure
| PDB | 6HLS |
| External Links | |
| Method | ELECTRON MICROSCOPY |
| Organism | |
| Primary Citation |
The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2.
Elife
|
