CATH Classification
Level | CATH Code | Description |
---|---|---|
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1 | Mainly Alpha |
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1.10 | Orthogonal Bundle |
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1.10.510 | Transferase(Phosphotransferase); domain 1 |
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1.10.510.10 | Transferase(Phosphotransferase) domain 1 |
Domain Context
CATH Clusters
Superfamily | Transferase(Phosphotransferase) domain 1 |
Functional Family | Non-specific serine/threonine protein kinase |
Enzyme Information
2.7.11.1 |
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P31749
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
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UniProtKB Entries (1)
P31749 |
AKT1_HUMAN
Homo sapiens
RAC-alpha serine/threonine-protein kinase
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PDB Structure
PDB | 6HHJ |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt.
Chem Sci
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