CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.300 | GMP Synthetase; Chain A, domain 3 |
|
3.30.300.330 |
Domain Context
CATH Clusters
| Superfamily | 3.30.300.330 |
| Functional Family | Alkylglycerone-phosphate synthase |
Enzyme Information
| 2.5.1.26 |
Alkylglycerone-phosphate synthase.
based on mapping to UniProt P97275
1-acyl-glycerone 3-phosphate + a long-chain alcohol = an alkyl-glycerone 3-phosphate + a long-chain acid anion.
-!- The ester-linked fatty acid of the substrate is cleaved and replaced by a long-chain alcohol in an ether linkage.
|
UniProtKB Entries (1)
| P97275 |
ADAS_CAVPO
Cavia porcellus
Alkyldihydroxyacetonephosphate synthase, peroxisomal
|
PDB Structure
| PDB | 6GOU |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells.
Eur J Med Chem
|
