1 keywords

CATH Domain 6gouD04

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.70 Alpha-Beta Plaits
Homologous Superfamily 3.30.70.3450  

Domain Context

CATH Clusters

Superfamily 3.30.70.3450
Functional Family Alkylglycerone-phosphate synthase

Enzyme Information

2.5.1.26
Alkylglycerone-phosphate synthase.
based on mapping to UniProt P97275
1-acyl-glycerone 3-phosphate + a long-chain alcohol = an alkyl-glycerone 3-phosphate + a long-chain acid anion.
-!- The ester-linked fatty acid of the substrate is cleaved and replaced by a long-chain alcohol in an ether linkage.

UniProtKB Entries (1)

P97275
ADAS_CAVPO
Cavia porcellus
Alkyldihydroxyacetonephosphate synthase, peroxisomal

PDB Structure

PDB 6GOU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells.
Stazi, G., Battistelli, C., Piano, V., Mazzone, R., Marrocco, B., Marchese, S., Louie, S.M., Zwergel, C., Antonini, L., Patsilinakos, A., Ragno, R., Viviano, M., Sbardella, G., Ciogli, A., Fabrizi, G., Cirilli, R., Strippoli, R., Marchetti, A., Tripodi, M., Nomura, D.K., Mattevi, A., Mai, A., Valente, S.
Eur J Med Chem