CATH Domain 6gouD01

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.43	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2
	3.30.43.10	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2

Superfamily	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2
Functional Family	Alkylglycerone-phosphate synthase

2.5.1.26

Alkylglycerone-phosphate synthase.

based on mapping to UniProt P97275

1-acyl-glycerone 3-phosphate + a long-chain alcohol = an alkyl-glycerone 3-phosphate + a long-chain acid anion.

-!- The ester-linked fatty acid of the substrate is cleaved and replaced by a long-chain alcohol in an ether linkage.

ADAS_CAVPO

Cavia porcellus

Alkyldihydroxyacetonephosphate synthase, peroxisomal

PDB	6GOU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells. Stazi, G., Battistelli, C., Piano, V., Mazzone, R., Marrocco, B., Marchese, S., Louie, S.M., Zwergel, C., Antonini, L., Patsilinakos, A., Ragno, R., Viviano, M., Sbardella, G., Ciogli, A., Fabrizi, G., Cirilli, R., Strippoli, R., Marchetti, A., Tripodi, M., Nomura, D.K., Mattevi, A., Mai, A., Valente, S. Eur J Med Chem