CATH Domain 6g40C02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1670	Endonuclease Iii, domain 2
	1.10.1670.10	Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)

Domain Context

CATH Clusters

Superfamily	Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)
Functional Family	N-glycosylase/DNA lyase OGG1

Enzyme Information

4.2.99.18

DNA-(apurinic or apyrimidinic site) lyase.

based on mapping to UniProt O08760

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

-!- 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis. -!- This group of enzymes was previously listed as endonucleases, under the number EC 3.1.25.2.

3.2.2.-

Hydrolyzing N-glycosyl compounds.

based on mapping to UniProt O08760

UniProtKB Entries (1)

O08760

OGG1_MOUSE

Mus musculus

N-glycosylase/DNA lyase

PDB Structure

PDB	6G40
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Small molecule inhibitor of OGG1 suppresses pro-inflammatory gene expression and inflammation Visnes, T., Cazares-Korner, A., Hao, W., Wallner, O., Masuyer, G., Loseva, O., Mortusewicz, O., Wiita, E., Sarno, A., Manoilov, A., Astorga-Wells, J., Jemth, A.S., Karsten, S., Gokturk, C., Grube, M., Homan, E.J., Scobie, M., Paulin, C.B.J., Krokan, H.E., Baranczewski, P., Artursson, P., Altun, M., Jensen, A.J., Lundback, T., Zubarev, R.A., Stenmark, P., Boldogh, I., Helleday, T. To Be Published