CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.30 | 2-Layer Sandwich |
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3.30.310 | TATA-Binding Protein |
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3.30.310.40 |
Domain Context
CATH Clusters
Superfamily | 3.30.310.40 |
Functional Family | N-glycosylase/DNA lyase isoform X2 |
Enzyme Information
4.2.99.18 |
DNA-(apurinic or apyrimidinic site) lyase.
based on mapping to UniProt O08760
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
-!- 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis. -!- This group of enzymes was previously listed as endonucleases, under the number EC 3.1.25.2.
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3.2.2.- |
Hydrolyzing N-glycosyl compounds.
based on mapping to UniProt O08760
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UniProtKB Entries (1)
O08760 |
OGG1_MOUSE
Mus musculus
N-glycosylase/DNA lyase
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PDB Structure
PDB | 6G3X |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.
Science
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