CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.390 | Neutral Protease; domain 2 |
|
1.10.390.10 | Neutral Protease Domain 2 |
Domain Context
CATH Clusters
| Superfamily | Neutral Protease Domain 2 |
| Functional Family | Thermolysin |
Enzyme Information
| 3.4.24.26 |
Pseudolysin.
based on mapping to UniProt P14756
Hydrolysis of proteins including elastin, collagen types III and IV, fibronectin and immunoglobulin A, generally with bulky hydrophobic group at P1'. Insulin B chain cleavage pattern identical to that of thermolysin, but specificity differs in other respects.
-!- Causes tissue damage. -!- Belongs to peptidase family M4. -!- Formerly EC 3.4.24.4.
|
UniProtKB Entries (1)
| P14756 |
ELAS_PSEAE
Pseudomonas aeruginosa PAO1
Elastase
|
PDB Structure
| PDB | 6FZX |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Tackling Pseudomonas aeruginosa Virulence by a Hydroxamic Acid-Based LasB Inhibitor.
ACS Chem. Biol.
|
