CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.110 | Butyryl-CoA Dehydrogenase, subunit A; domain 2 |
|
2.40.110.10 | Butyryl-CoA Dehydrogenase, subunit A, domain 2 |
Domain Context
CATH Clusters
| Superfamily | Butyryl-CoA Dehydrogenase, subunit A, domain 2 |
| Functional Family | Acyl-CoA dehydrogenase, mitochondrial |
Enzyme Information
| 1.3.1.108 |
Caffeoyl-CoA reductase.
based on mapping to UniProt H6LGM6
3-(3,4-dihydroxyphenyl)propanoyl-CoA + 2 NAD(+) + 2 reduced ferredoxin [iron-sulfur] cluster = (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl-CoA + 2 NADH + 2 oxidized ferredoxin [iron-sulfur] cluster.
-!- The enzyme, characterized from the bacterium Acetobacterium woodii, couples the endergonic ferredoxin reduction with NADH as reductant to the exergonic reduction of caffeoyl-CoA with the same reductant. -!- It uses the mechanism of electron bifurcation to overcome the steep energy barrier in ferredoxin reduction. -!- It also reduces 4-coumaroyl-CoA and feruloyl-CoA.
|
UniProtKB Entries (1)
| H6LGM8 |
CARE_ACEWD
Acetobacterium woodii DSM 1030
Caffeyl-CoA reductase-Etf complex subunit CarE
|
PDB Structure
| PDB | 6FAH |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Molecular basis of the flavin-based electron-bifurcating caffeyl-CoA reductase reaction.
FEBS Lett.
|