CATH Classification

Domain Context

CATH Clusters

Functional Family Caspase-1

Enzyme Information
based on mapping to UniProt P29466
Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.
-!- Part of the family of inflammatory-caspases, which also includes caspase-4 (EC and caspase-5 (EC in humans and caspase-11 (EC, caspase-12, caspase-13 and caspase-14 in mice. -!- Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. -!- Cleaves pro-interleukin-1-beta (pro-IL-1-beta) to form mature IL-1- beta, a potent mediator of inflammation. -!- Also activates the proinflammatory cytokine, IL-18, which is also known as interferon-gamma-inducing factor. -!- Inhibited by Ac-Tyr-Val-Ala-Asp-CHO. -!- Caspase-11 plays a critical role in the activation of caspase-1 in mice whereas caspase-4 enhances its activation in humans. -!- Belongs to peptidase family C14.

UniProtKB Entries (1)

Homo sapiens

PDB Structure

External Links
Primary Citation
Rational Drug Design of Topically Administered Caspase 1 Inhibitors for the Treatment of Inflammatory Acne.
Fournier, J.F., Clary, L., Chambon, S., Dumais, L., Harris, C.S., Millois, C., Pierre, R., Talano, S., Thoreau, E., Aubert, J., Aurelly, M., Bouix-Peter, C., Brethon, A., Chantalat, L., Christin, O., Comino, C., El-Bazbouz, G., Ghilini, A.L., Isabet, T., Lardy, C., Luzy, A.P., Mathieu, C., Mebrouk, K., Orfila, D., Pascau, J., Reverse, K., Roche, D., Rodeschini, V., Hennequin, L.F.
J. Med. Chem.