CATH Domain 6eweA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.60	4-Layer Sandwich
	3.60.15	Metallo-beta-lactamase; Chain A
	3.60.15.10	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

Domain Context

CATH Clusters

Superfamily	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Functional Family	Metallo-beta-lactamase type 2

Enzyme Information

3.5.2.6

Beta-lactamase.

based on mapping to UniProt P04190

A beta-lactam + H(2)O = a substituted beta-amino acid.

-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P04190

BLA2_BACCE

Bacillus cereus

Metallo-beta-lactamase type 2

PDB Structure

PDB	6EWE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-beta-lactamases. Zhang, D., Markoulides, M.S., Stepanovs, D., Rydzik, A.M., El-Hussein, A., Bon, C., Kamps, J.J.A.G., Umland, K.D., Collins, P.M., Cahill, S.T., Wang, D.Y., von Delft, F., Brem, J., McDonough, M.A., Schofield, C.J. Bioorg. Med. Chem.