CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.47 | Peroxisomal Thiolase; Chain A, domain 1 |
|
3.40.47.10 | Thiolase/Chalcone synthase |
Domain Context
CATH Clusters
| Superfamily | 3.40.47.10 |
| Functional Family |
Enzyme Information
| 2.3.1.230 |
2-heptyl-4(1H)-quinolone synthase.
based on mapping to UniProt Q9I4X1
Octanoyl-CoA + 2-aminobenzoylacetate = 2-heptyl-4(1H)-quinolone + CoA + CO(2) + H(2)O.
-!- The enzyme, characterized from the bacterium Pseudomonas aeruginosa, is a heterodimeric complex. -!- The PqsC subunit acquires an octanoyl group from octanoyl-CoA and attaches it to an internal cysteine residue. -!- Together with the PqsB subunit, the proteins catalyze the coupling of the octanoyl group with (2-aminobenzoyl)acetate, leading to decarboxylation and dehydration events that result in closure of the quinoline ring.
|
UniProtKB Entries (1)
| Q9I4X1 |
PQSC_PSEAE
Pseudomonas aeruginosa PAO1
2-heptyl-4(1H)-quinolone synthase subunit PqsC
|
PDB Structure
| PDB | 6ESZ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The Alkylquinolone Repertoire of Pseudomonas aeruginosa is Linked to Structural Flexibility of the FabH-like 2-Heptyl-3-hydroxy-4(1H)-quinolone (PQS) Biosynthesis Enzyme PqsBC.
Chembiochem
|