CATH Domain 6es0A00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Receptor-interacting serine/threonine-protein kinase 2

Enzyme Information

2.7.11.1	Non-specific serine/threonine protein kinase. based on mapping to UniProt O43353 ATP + a protein = ADP + a phosphoprotein. -!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
2.7.10.2	Non-specific protein-tyrosine kinase. based on mapping to UniProt O43353 ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. -!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

RIPK2_HUMAN

Homo sapiens

Receptor-interacting serine/threonine-protein kinase 2

PDB Structure

PDB	6ES0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors. Suebsuwong, C., Pinkas, D.M., Ray, S.S., Bufton, J.C., Dai, B., Bullock, A.N., Degterev, A., Cuny, G.D. Bioorg. Med. Chem. Lett.