CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside phosphorylase domain
Functional Family Aminodeoxyfutalosine nucleosidase

Enzyme Information

3.2.2.9
Adenosylhomocysteine nucleosidase.
based on mapping to UniProt Q9ZMY2
S-adenosyl-L-homocysteine + H(2)O = S-(5-deoxy-D-ribos-5-yl)-L- homocysteine + adenine.
3.2.2.30
Aminodeoxyfutalosine nucleosidase.
based on mapping to UniProt Q9ZMY2
6-amino-6-deoxyfutalosine + H(2)O = dehypoxanthine futalosine + adenine.
-!- The enzyme, found in several bacterial species, catalyzes a step in a modified futalosine pathway for menaquinone biosynthesis. -!- While the enzyme from some organisms also has the activity of EC 3.2.2.9 the enzyme from Chlamydia trachomatis is specific for 6-amino-6-deoxyfutalosine.

UniProtKB Entries (1)

Q9ZMY2
MQMTN_HELPJ
Helicobacter pylori J99
Aminodeoxyfutalosine nucleosidase

PDB Structure

PDB 6DYV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase.
Harijan, R.K., Hoff, O., Ducati, R.G., Firestone, R.S., Hirsch, B.M., Evans, G.B., Schramm, V.L., Tyler, P.C.
J. Med. Chem.