CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.40 | 3-Layer(aba) Sandwich |
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3.40.47 | Peroxisomal Thiolase; Chain A, domain 1 |
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3.40.47.10 | Thiolase/Chalcone synthase |
Domain Context
CATH Clusters
Superfamily | 3.40.47.10 |
Functional Family | Chalcone synthase 2 |
Enzyme Information
2.3.1.74 |
Chalcone synthase.
based on mapping to UniProt P13114
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO(2).
-!- The enzyme catalyzes the first committed step in the biosynthesis of flavonoids. -!- It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
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UniProtKB Entries (1)
P13114 |
CHSY_ARATH
Arabidopsis thaliana
Chalcone synthase
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PDB Structure
PDB | 6DXD |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Mechanistic basis for the evolution of chalcone synthase catalytic cysteine reactivity in land plants.
J. Biol. Chem.
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