CATH Classification

Domain Context

CATH Clusters

Superfamily L-arginine/glycine Amidinotransferase; Chain A
Functional Family N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

Enzyme Information

3.5.3.18
Dimethylargininase.
based on mapping to UniProt O94760
N(omega),N(omega)-dimethyl-L-arginine + H(2)O = dimethylamine + L-citrulline.
-!- Also acts on N(omega)-methyl-L-arginine.

UniProtKB Entries (1)

O94760
DDAH1_HUMAN
Homo sapiens
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

PDB Structure

PDB 6DGE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Dissection, Optimization, and Structural Analysis of a Covalent Irreversible DDAH1 Inhibitor.
Burstein-Teitelbaum, G., Er, J.A.V., Monzingo, A.F., Tuley, A., Fast, W.
Biochemistry