CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family O-methyltransferase ZRP4

Enzyme Information

2.1.1.150
Isoflavone 7-O-methyltransferase.
based on mapping to UniProt O24529
S-adenosyl-L-methionine + a 7-hydroxyisoflavone = S-adenosyl-L- homocysteine + a 7-methoxyisoflavone.
-!- The enzyme from alfalfa can methylate daidzein, genistein and 6,7,4'-trihydroxyisoflavone but not flavones or flavanones.

UniProtKB Entries (1)

O24529
7OMT8_MEDSA
Medicago sativa
Isoflavone-7-O-methyltransferase 8

PDB Structure

PDB 6CIG
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structures of two natural product methyltransferases reveal the basis for substrate specificity in plant O-methyltransferases.
Zubieta, C., He, X.Z., Dixon, R.A., Noel, J.P.
Nat. Struct. Biol.
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