CATH Domain 6chmA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.620	HUPs

Domain Context

CATH Clusters

Superfamily	HUPs
Functional Family	Phosphopantetheine adenylyltransferase

Enzyme Information

2.7.7.3

Pantetheine-phosphate adenylyltransferase.

based on mapping to UniProt P0A6I6

ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA.

-!- The enzyme from several bacteria (e.g. Escherichia coli, Bacillus subtilis and Haemophilus influenzae) has been shown to be bifunctional and also to possess the activity of EC 2.3.1.157.

UniProtKB Entries (1)

P0A6I6

COAD_ECOLI

Escherichia coli K-12

Phosphopantetheine adenylyltransferase

PDB Structure

PDB	6CHM
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity. Skepper, C.K., Moreau, R.J., Appleton, B.A., Benton, B.M., Drumm, J.E., Feng, B.Y., Geng, M., Hu, C., Li, C., Lingel, A., Lu, Y., Mamo, M., Mergo, W., Mostafavi, M., Rath, C.M., Steffek, M., Takeoka, K.T., Uehara, K., Wang, L., Wei, J.R., Xie, L., Xu, W., Zhang, Q., de Vicente, J. J. Med. Chem.