CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.1150 | Aspartate Aminotransferase, domain 1 |
|
3.90.1150.10 | Aspartate Aminotransferase, domain 1 |
Domain Context
CATH Clusters
| Superfamily | Aspartate Aminotransferase, domain 1 |
| Functional Family | 4-aminobutyrate aminotransferase, mitochondrial |
Enzyme Information
| 2.6.1.22 |
(S)-3-amino-2-methylpropionate transaminase.
based on mapping to UniProt P80147
(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3- oxopropanoate + L-glutamate.
-!- Also acts on beta-alanine and other omega-amino acids having carbon chains between 2 and 5. -!- The two enantiomers of the 2-methyl-3-oxopropanoate formed by the enzyme interconvert by enolization, so that this enzyme, together with EC 2.6.1.40, provide a route for interconversion of the enantiomers of 3-amino-2-methylpropanoate.
|
| 2.6.1.19 |
4-aminobutyrate--2-oxoglutarate transaminase.
based on mapping to UniProt P80147
4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.
-!- Some preparations also act on beta-alanine, 5-aminopentanoate and (R,S)-3-amino-2-methylpropanoate.
|
UniProtKB Entries (1)
| P80147 |
GABT_PIG
Sus scrofa
4-aminobutyrate aminotransferase, mitochondrial
|
PDB Structure
| PDB | 6B6G |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent gamma-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction.
J. Am. Chem. Soc.
|
