CATH Classification

Domain Context

CATH Clusters

Superfamily 2.170.220.10
Functional Family Methionine--tRNA ligase

Enzyme Information

6.1.1.10
Methionine--tRNA ligase.
based on mapping to UniProt P9WFU5
ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl- tRNA(Met).
-!- In those organisms producing N-formylmethionyl-tRNA(fMet) for translation initiation, this enzyme also recognizes the initiator tRNA(fMet) and catalyzes the formation of L-methionyl-tRNA(fMet), the substrate for EC 2.1.2.9.

UniProtKB Entries (1)

P9WFU5
SYM_MYCTU
Mycobacterium tuberculosis H37Rv
Methionine--tRNA ligase

PDB Structure

PDB 6AX8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate.
Barros-Alvarez, X., Turley, S., Ranade, R.M., Gillespie, J.R., Duster, N.A., Verlinde, C.L.M.J., Fan, E., Buckner, F.S., Hol, W.G.J.
Acta Crystallogr F Struct Biol Commun