CATH Classification

Domain Context

CATH Clusters

Superfamily succinate dehydrogenase protein domain
Functional Family Fumarate reductase flavoprotein subunit

Enzyme Information

1.3.5.4
Fumarate reductase (quinol).
based on mapping to UniProt P00363
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme, which is found in anaerobic and facultative organisms such as bacteria, parasitic helminthes, and lower marine organisms, utilizes low potential quinols, such as menaquinol and rhodoquinol, to reduce fumarate as the final step of an anaerobic respiratory chain. -!- The enzyme is known as complex II of the electron transfer chain, similarly to EC 1.3.5.1, to which it is closely related.

UniProtKB Entries (3)

P00363
FRDA_ECOLI
Escherichia coli K-12
Fumarate reductase flavoprotein subunit
B7MKV8
FRDD_ECO45
Escherichia coli S88
Fumarate reductase subunit D
P0AC49
FRDB_ECO57
Escherichia coli O157:H7
Fumarate reductase iron-sulfur subunit

PDB Structure

PDB 6AWF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
New crystal forms of the integral membrane Escherichia coli quinol:fumarate reductase suggest that ligands control domain movement.
Starbird, C.A., Tomasiak, T.M., Singh, P.K., Yankovskaya, V., Maklashina, E., Eisenbach, M., Cecchini, G., Iverson, T.M.
J. Struct. Biol.