CATH Domain 6awfA03

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.58	Methane Monooxygenase Hydroxylase; Chain G, domain 1
	1.20.58.100	Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain

Domain Context

CATH Clusters

Superfamily	Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain
Functional Family	Succinate dehydrogenase flavoprotein subunit (SdhA)

Enzyme Information

1.3.5.4

Fumarate reductase (quinol).

based on mapping to UniProt P00363

Succinate + a quinone = fumarate + a quinol.

-!- The enzyme, which is found in anaerobic and facultative organisms such as bacteria, parasitic helminthes, and lower marine organisms, utilizes low potential quinols, such as menaquinol and rhodoquinol, to reduce fumarate as the final step of an anaerobic respiratory chain. -!- The enzyme is known as complex II of the electron transfer chain, similarly to EC 1.3.5.1, to which it is closely related.

UniProtKB Entries (3)

P00363	FRDA_ECOLI Escherichia coli K-12 Fumarate reductase flavoprotein subunit
B7MKV8	FRDD_ECO45 Escherichia coli S88 Fumarate reductase subunit D
P0AC49	FRDB_ECO57 Escherichia coli O157:H7 Fumarate reductase iron-sulfur subunit

PDB Structure

PDB	6AWF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	New crystal forms of the integral membrane Escherichia coli quinol:fumarate reductase suggest that ligands control domain movement. Starbird, C.A., Tomasiak, T.M., Singh, P.K., Yankovskaya, V., Maklashina, E., Eisenbach, M., Cecchini, G., Iverson, T.M. J. Struct. Biol.