CATH Domain 6atkC04

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.25	Alpha Horseshoe
	1.25.50	Zincin-like fold
	1.25.50.20

Domain Context

CATH Clusters

Superfamily	1.25.50.20
Functional Family	Aminopeptidase N

Enzyme Information

3.4.11.2

Membrane alanyl aminopeptidase.

based on mapping to UniProt P15144

Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.

-!- Is not activated by heavy metal ions. -!- Belongs to peptidase family M1. -!- Formerly EC 3.4.1.2, EC 3.4.3.5 and EC 3.4.13.6.

UniProtKB Entries (2)

P15423	SPIKE_CVH22 Human coronavirus 229E Spike glycoprotein
P15144	AMPN_HUMAN Homo sapiens Aminopeptidase N

PDB Structure

PDB	6ATK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Receptor-binding loops in alphacoronavirus adaptation and evolution. Wong, A.H.M., Tomlinson, A.C.A., Zhou, D., Satkunarajah, M., Chen, K., Sharon, C., Desforges, M., Talbot, P.J., Rini, J.M. Nat Commun