1 keywords

CATH Domain 6akwA01

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.60 Sandwich
Topology 2.60.120 Jelly Rolls
Homologous Superfamily 2.60.120.590 Alpha-ketoglutarate-dependent dioxygenase AlkB-like

Domain Context

CATH Clusters

Superfamily Alpha-ketoglutarate-dependent dioxygenase AlkB-like
Functional Family FTO, alpha-ketoglutarate dependent dioxygenase

Enzyme Information

1.14.11.53
mRNA N(6)-methyladenine demethylase.
based on mapping to UniProt Q9C0B1
N(6)-methyladenosine in mRNA + 2-oxoglutarate + O(2) = adenosine in mRNA + formaldehyde + succinate + CO(2).
-!- Catalyzes oxidative demethylation of mRNA N(6)-methyladenine. -!- The FTO enzyme from human can also demethylate N(3)-methylthymine from single stranded DNA and N(3)-methyluridine from single stranded RNA with low activity.
1.14.11.-
With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.
based on mapping to UniProt Q9C0B1

UniProtKB Entries (1)

Q9C0B1
FTO_HUMAN
Homo sapiens
Alpha-ketoglutarate-dependent dioxygenase FTO

PDB Structure

PDB 6AKW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Huang, Y., Su, R., Sheng, Y., Dong, L., Dong, Z., Xu, H., Ni, T., Zhang, Z.S., Zhang, T., Li, C., Han, L., Zhu, Z., Lian, F., Wei, J., Deng, Q., Wang, Y., Wunderlich, M., Gao, Z., Pan, G., Zhong, D., Zhou, H., Zhang, N., Gan, J., Jiang, H., Mulloy, J.C., Qian, Z., Chen, J., Yang, C.G.
Cancer Cell