CATH Domain 6akwA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.120	Jelly Rolls
	2.60.120.590	Alpha-ketoglutarate-dependent dioxygenase AlkB-like

Domain Context

CATH Clusters

Superfamily	Alpha-ketoglutarate-dependent dioxygenase AlkB-like
Functional Family	FTO, alpha-ketoglutarate dependent dioxygenase

Enzyme Information

1.14.11.53

mRNA N(6)-methyladenine demethylase.

based on mapping to UniProt Q9C0B1

N(6)-methyladenosine in mRNA + 2-oxoglutarate + O(2) = adenosine in mRNA + formaldehyde + succinate + CO(2).

-!- Catalyzes oxidative demethylation of mRNA N(6)-methyladenine. -!- The FTO enzyme from human can also demethylate N(3)-methylthymine from single stranded DNA and N(3)-methyluridine from single stranded RNA with low activity.

1.14.11.-

With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.

based on mapping to UniProt Q9C0B1

UniProtKB Entries (1)

Q9C0B1

FTO_HUMAN

Homo sapiens

Alpha-ketoglutarate-dependent dioxygenase FTO

PDB Structure

PDB	6AKW
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Huang, Y., Su, R., Sheng, Y., Dong, L., Dong, Z., Xu, H., Ni, T., Zhang, Z.S., Zhang, T., Li, C., Han, L., Zhu, Z., Lian, F., Wei, J., Deng, Q., Wang, Y., Wunderlich, M., Gao, Z., Pan, G., Zhong, D., Zhou, H., Zhang, N., Gan, J., Jiang, H., Mulloy, J.C., Qian, Z., Chen, J., Yang, C.G. Cancer Cell