CATH Classification

Domain Context

CATH Clusters

Superfamily Butyryl-CoA Dehydrogenase, subunit A, domain 2
Functional Family L-prolyl-[peptidyl-carrier protein] dehydrogenase

Enzyme Information

1.3.8.14
L-prolyl-[peptidyl-carrier protein] dehydrogenase.
based on mapping to UniProt Q5W271
L-prolyl-[peptidyl-carrier protein] + 2 electron-transfer flavoprotein = 1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] + 2 reduced electron- transfer flavoprotein.
-!- The enzyme participates in the biosynthesis of several pyrrole- containing compounds, such as undecylprodigiosin, prodigiosin, pyoluteorin, and coumermycin A1. -!- It is believed to catalyze the formation of a Delta(2)-pyrrolin-2- yl(carbonyl)-S-[peptidyl-carrier protein] intermediate, followed by a two-electron oxidation to 1H-pyrrol-2-carbonyl-[peptidyl-carrier protein].

UniProtKB Entries (1)

Q5W271
PIGA_SERS3
Serratia sp. ATCC 39006
L-prolyl-[peptidyl-carrier protein] dehydrogenase

PDB Structure

PDB 6AF6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of PigA: A Prolyl Thioester-Oxidizing Enzyme in Prodigiosin Biosynthesis.
Lee, C.-C., Ko, T.-P., Chen, C.T., Chan, Y.T., Lo, S.Y., Chang, J.Y., Chen, Y.W., Chung, T.F., Hsieh, H.J., Hsiao, C.D., Wang, A.H.J.
Chembiochem
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