CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.21.117
Stratum corneum chymotryptic enzyme.
based on mapping to UniProt P49862
Cleavage of proteins with aromatic side chains in the P1 position.
-!- This enzyme has wide substrate specificity, being able to degrade heat-denatured bovine casein and the alpha-chain of native human fibrinogen. -!- It cleaves the B chain of bovine insulin at 6-Leu-|-Cya-7 (cysteic acid), 16-Tyr-|-Leu-17, 25-Phe-|-Tyr-26 and 26-Tyr-|-Thr-27. -!- It is thought to play a role in the desquamation (skin-shedding) of the outer layer of skin, the stratum corneum, by degrading intercellular cohesive structures. -!- Belongs to peptidase family S1A.

UniProtKB Entries (1)

P49862
KLK7_HUMAN
Homo sapiens
Kallikrein-7

PDB Structure

PDB 5YJK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery and structure-activity relationship study of 1,3,6-trisubstituted 1,4-diazepane-7-ones as novel human kallikrein 7 inhibitors
Murafuji, H., Sakai, H., Goto, M., Imajo, S., Sugawara, H., Muto, T.
Bioorg. Med. Chem. Lett.