CATH Domain 5xv7A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	SRSF protein kinase 2

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt Q96SB4

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q96SB4

SRPK1_HUMAN

Homo sapiens

SRSF protein kinase 1

PDB Structure

PDB	5XV7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform Hatcher, J.M., Wu, G., Zeng, C., Zhu, J., Meng, F., Patel, S., Wang, W., Ficarro, S.B., Leggett, A.L., Powell, C.E., Marto, J.A., Zhang, K., Ki Ngo, J.C., Fu, X.D., Zhang, T., Gray, N.S. Cell Chem Biol