CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family N(4)-bis(aminopropyl)spermidine synthase

Enzyme Information

2.5.1.128
N(4)-bis(aminopropyl)spermidine synthase.
based on mapping to UniProt Q5JIZ3
2 S-adenosyl 3-(methylthio)propylamine + spermidine = 2 S-methyl- 5'-thioadenosine + N(4)-bis(aminopropyl)spermidine.
-!- The enzyme, characterized from the thermophilic archaeon Thermococcus kodakarensis, synthesizes the branched-chain polyamine N(4)- bis(aminopropyl)spermidine, which is required for cell growth at high-temperature. -!- When spermine is used as substrate, the enzyme forms N(4)- aminopropylspermine.

UniProtKB Entries (1)

Q5JIZ3
BPSA_THEKO
Thermococcus kodakarensis KOD1
N(4)-bis(aminopropyl)spermidine synthase

PDB Structure

PDB 5XNH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Active site geometry of a novel aminopropyltransferase for biosynthesis of hyperthermophile-specific branched-chain polyamine.
Hidese, R., Tse, K.M., Kimura, S., Mizohata, E., Fujita, J., Horai, Y., Umezawa, N., Higuchi, T., Niitsu, M., Oshima, T., Imanaka, T., Inoue, T., Fujiwara, S.
FEBS J.
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