CATH Domain 5xe1A01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.58	Methane Monooxygenase Hydroxylase; Chain G, domain 1
	1.20.58.480

Domain Context

CATH Clusters

Superfamily	1.20.58.480
Functional Family

Enzyme Information

1.13.11.52

Indoleamine 2,3-dioxygenase.

based on mapping to UniProt P14902

(1) D-tryptophan + O(2) = N-formyl-D-kynurenine. (2) L-tryptophan + O(2) = N-formyl-L-kynurenine.

-!- Requires ascorbic acid and methylene blue for activity. -!- Has broader substrate specificity than EC 1.13.11.11. -!- Is induced in response to pathological conditions and host-defense mechanisms. -!- While the enzyme is more active with D-tryptophan than L-tryptophan, its only known function to date is in the metabolism of L-tryptophan. -!- Superoxide radicals can replace O(2) as oxygen donor.

UniProtKB Entries (1)

P14902

I23O1_HUMAN

Homo sapiens

Indoleamine 2,3-dioxygenase 1

PDB Structure

PDB	5XE1
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural insights into the binding mechanism of IDO1 with hydroxylamidine based inhibitor INCB14943 Wu, Y., Xu, T., Liu, J., Ding, K., Xu, J. Biochem. Biophys. Res. Commun.