CATH Classification

Domain Context

CATH Clusters

Superfamily 3.90.940.10
Functional Family

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt Q72ID6
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (2)

Q8RQE9
RPOB_THET8
Thermus thermophilus HB8
DNA-directed RNA polymerase subunit beta
Q72L95
SIGA_THET2
Thermus thermophilus HB27
RNA polymerase sigma factor SigA

PDB Structure

PDB 5X22
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase.
Maffioli, S.I., Zhang, Y., Degen, D., Carzaniga, T., Del Gatto, G., Serina, S., Monciardini, P., Mazzetti, C., Guglierame, P., Candiani, G., Chiriac, A.I., Facchetti, G., Kaltofen, P., Sahl, H.G., Deho, G., Donadio, S., Ebright, R.H.
Cell