CATH Domain 5x0zD02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.150	Vaccinia Virus protein VP39

Domain Context

CATH Clusters

Superfamily	Vaccinia Virus protein VP39
Functional Family	Polyamine aminopropyltransferase

Enzyme Information

2.5.1.16

Spermidine synthase.

based on mapping to UniProt O25503

S-adenosyl 3-(methylthio)propylamine + putrescine = 5'-S-methyl- 5'-thioadenosine + spermidine.

-!- The enzymes from the plant Glycine max and from mammalia are highly specific for putrescine as the amine acceptor. -!- The enzymes from the bacteria Escherichia coli and Thermotoga maritima prefer putrescine but are more tolerant toward other amine acceptors, such as spermidine and cadaverine. -!- Cf. EC 2.5.1.22 and EC 2.5.1.23.

UniProtKB Entries (1)

O25503

SPEE_HELPY

Helicobacter pylori 26695

Polyamine aminopropyltransferase

PDB Structure

PDB	5X0Z
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A putative spermidine synthase interacts with flagellar switch protein FliM and regulates motility in Helicobacter pylori Zhang, H., Lam, K.H., Lam, W.W.L., Wong, S.Y.Y., Chan, V.S.F., Au, S.W.N. Mol. Microbiol.