CATH Classification

Domain Context

CATH Clusters

Functional Family Genome polyprotein

Enzyme Information
Picornain 3C.
based on mapping to UniProt P08617
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
-!- From entero-, rhino-, aphto- and cardioviruses. -!- Larger than the homologous virus picornain 2A. -!- Belongs to peptidase family C3.
Nucleoside-triphosphate phosphatase.
based on mapping to UniProt P08617
NTP + H(2)O = NDP + phosphate.
-!- The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. -!- Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD. -!- The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
RNA-directed RNA polymerase.
based on mapping to UniProt P08617
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC

UniProtKB Entries (1)

Human hepatitis A virus Hu/Australia/HM175/1976
Genome polyprotein

PDB Structure

External Links
Primary Citation
Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site
Wang, X., Zhu, L., Dang, M., Hu, Z., Gao, Q., Yuan, S., Sun, Y., Zhang, B., Ren, J., Kotecha, A., Walter, T.S., Wang, J., Fry, E.E., Stuart, D.I., Rao, Z.
Proc. Natl. Acad. Sci. U.S.A.