CATH Domain 5we8B02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Serine/threonine-protein kinase WNK1 isoform 2

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt Q9H4A3

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q9H4A3

WNK1_HUMAN

Homo sapiens

Serine/threonine-protein kinase WNK1

PDB Structure

PDB	5WE8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models. Yamada, K., Levell, J., Yoon, T., Kohls, D., Yowe, D., Rigel, D.F., Imase, H., Yuan, J., Yasoshima, K., DiPetrillo, K., Monovich, L., Xu, L., Zhu, M., Kato, M., Jain, M., Idamakanti, N., Taslimi, P., Kawanami, T., Argikar, U.A., Kunjathoor, V., Xie, X., Yagi, Y.I., Iwaki, Y., Robinson, Z., Park, H.M. J. Med. Chem.