CATH Domain 5vxzC00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.10	Immunoglobulins

Domain Context

CATH Clusters

Superfamily	Immunoglobulins
Functional Family	Tyrosine-protein kinase receptor UFO

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P30530

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q14393

GAS6_HUMAN

Homo sapiens

Growth arrest-specific protein 6

PDB Structure

PDB	5VXZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies. Kariolis, M.S., Miao, Y.R., Diep, A., Nash, S.E., Olcina, M.M., Jiang, D., Jones, D.S., Kapur, S., Mathews, I.I., Koong, A.C., Rankin, E.B., Cochran, J.R., Giaccia, A.J. J. Clin. Invest.