CATH Classification

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family Dipeptidyl peptidase 4

Enzyme Information

3.4.14.5
Dipeptidyl-peptidase IV.
based on mapping to UniProt P14740
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
-!- A membrane-bound serine-type peptidase in mammals. -!- EC 3.4.14.11 catalyzes a similar reaction. -!- Belongs to peptidase family S9B.

UniProtKB Entries (1)

P14740
DPP4_RAT
Rattus norvegicus
Dipeptidyl peptidase 4

PDB Structure

PDB 5VTA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-guided Discovery of Dual-recognition Chemibodies.
Cheng, A.C., Doherty, E.M., Johnstone, S., DiMauro, E.F., Dao, J., Luthra, A., Ye, J., Tang, J., Nixey, T., Min, X., Tagari, P., Miranda, L.P., Wang, Z.
Sci Rep