1 keywords

CATH Domain 5vlpA02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.200 Peptidase S8/S53 domain

Domain Context

CATH Clusters

Superfamily Peptidase S8/S53 domain
Functional Family Proprotein convertase subtilisin/kexin type 9

Enzyme Information

3.4.21.-
Serine endopeptidases.
based on mapping to UniProt Q8NBP7

UniProtKB Entries (1)

Q8NBP7
PCSK9_HUMAN
Homo sapiens
Proprotein convertase subtilisin/kexin type 9

PDB Structure

PDB 5VLP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists.
Zhang, Y., Ultsch, M., Skelton, N.J., Burdick, D.J., Beresini, M.H., Li, W., Kong-Beltran, M., Peterson, A., Quinn, J., Chiu, C., Wu, Y., Shia, S., Moran, P., Di Lello, P., Eigenbrot, C., Kirchhofer, D.
Nat. Struct. Mol. Biol.