1 keywords

CATH Domain 5vdwB01

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.1410 Poly(a)-polymerase, middle domain
Homologous Superfamily 1.10.1410.40  

Domain Context

CATH Clusters

Superfamily 1.10.1410.40
Functional Family Cyclic GMP-AMP synthase

Enzyme Information

2.7.7.86
Cyclic GMP-AMP synthase.
based on mapping to UniProt Q8N884
ATP + GTP = 2 diphosphate + cyclic G-P(2'-5')A-P(3'-5').
-!- Cyclic Gp(2'-5')Ap(3'-5') is a signaling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.

UniProtKB Entries (1)

Q8N884
CGAS_HUMAN
Homo sapiens
Cyclic GMP-AMP synthase

PDB Structure

PDB 5VDW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.
Hall, J., Ralph, E.C., Shanker, S., Wang, H., Byrnes, L.J., Horst, R., Wong, J., Brault, A., Dumlao, D., Smith, J.F., Dakin, L.A., Schmitt, D.C., Trujillo, J., Vincent, F., Griffor, M., Aulabaugh, A.E.
Protein Sci.