CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.10 | Roll |
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3.10.50 | Chitinase A; domain 3 |
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3.10.50.40 |
Domain Context
CATH Clusters
Superfamily | 3.10.50.40 |
Functional Family | Peptidyl-prolyl cis-trans isomerase Pin1 |
Enzyme Information
5.2.1.8 |
Peptidylprolyl isomerase.
based on mapping to UniProt Q13526
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.
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UniProtKB Entries (1)
Q13526 |
PIN1_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
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PDB Structure
PDB | 5UY9 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Prolyl isomerase PIN1 regulates the stability, transcriptional activity and oncogenic potential of BRD4.
Oncogene
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