CATH Domain 5uutB00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.630	Aminopeptidase
	3.40.630.170

Domain Context

CATH Clusters

Superfamily	3.40.630.170
Functional Family	Glycylpeptide N-tetradecanoyltransferase

Enzyme Information

2.3.1.97

Glycylpeptide N-tetradecanoyltransferase.

based on mapping to UniProt P30419

Tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal- N-tetradecanoylglycyl-[protein].

-!- The enzyme catalyzes the transfer of myristic acid from myristoyl-CoA to the amino group of the N-terminal glycine residue in a variety of eukaryotic proteins. -!- It uses an ordered Bi Bi reaction in which myristoyl-CoA binds to the enzyme prior to the binding of the peptide substrate, and CoA release precedes the release of the myristoylated peptide. -!- The enzyme from yeast is profoundly affected by amino acids further from the N-terminus, and is particularly stimulated by a serine residue at position 5.

UniProtKB Entries (1)

P30419

NMT1_HUMAN

Homo sapiens

Glycylpeptide N-tetradecanoyltransferase 1

PDB Structure

PDB	5UUT
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Blocking Myristoylation of Src Inhibits Its Kinase Activity and Suppresses Prostate Cancer Progression. Kim, S., Alsaidan, O.A., Goodwin, O., Li, Q., Sulejmani, E., Han, Z., Bai, A., Albers, T., Beharry, Z., Zheng, Y.G., Norris, J.S., Szulc, Z.M., Bielawska, A., Lebedyeva, I., Pegan, S.D., Cai, H. Cancer Res.