CATH Domain 5usrG02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.640	Aspartate Aminotransferase; domain 2
	3.40.640.10	Type I PLP-dependent aspartate aminotransferase-like (Major domain)

Domain Context

CATH Clusters

Superfamily	Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family	Cysteine desulfurase IscS

Enzyme Information

2.8.1.7

Cysteine desulfurase.

based on mapping to UniProt Q9Y697

L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor.

-!- The sulfur from free L-cysteine is first transferred to a cysteine residue in the active site, and then passed on to various other acceptors. -!- The enzyme is involved in the biosynthesis of iron-sulfur clusters, thio-nucleosides in tRNA, thiamine, biotin, lipoate and pyranopterin (molybdopterin). -!- In Azotobacter vinelandii, this sulfur provides the inorganic sulfide required for nitrogenous metallocluster formation.

UniProtKB Entries (2)

P0A6A8	ACP_ECOLI Escherichia coli K-12 Acyl carrier protein
Q9Y697	NFS1_HUMAN Homo sapiens Cysteine desulfurase, mitochondrial

PDB Structure

PDB	5USR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions. Cory, S.A., Van Vranken, J.G., Brignole, E.J., Patra, S., Winge, D.R., Drennan, C.L., Rutter, J., Barondeau, D.P. Proc. Natl. Acad. Sci. U.S.A.