1 keywords

CATH Domain 5uq9H02

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.1040 N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Homologous Superfamily 1.10.1040.10 N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2

Domain Context

CATH Clusters

Superfamily N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Functional Family 6-phosphogluconate dehydrogenase, decarboxylating

Enzyme Information

1.1.1.44
Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating).
based on mapping to UniProt P52209
6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.
-!- The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. -!- Highly specific for NADP(+). -!- Cf. EC 1.1.1.343.

UniProtKB Entries (1)

P52209
6PGD_HUMAN
Homo sapiens
6-phosphogluconate dehydrogenase, decarboxylating

PDB Structure

PDB 5UQ9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation.
Sun, Y., Bandi, M., Lofton, T., Smith, M., Bristow, C.A., Carugo, A., Rogers, N., Leonard, P., Chang, Q., Mullinax, R., Han, J., Shi, X., Seth, S., Meyers, B.A., Miller, M., Miao, L., Ma, X., Feng, N., Giuliani, V., Geck Do, M., Czako, B., Palmer, W.S., Mseeh, F., Asara, J.M., Jiang, Y., Morlacchi, P., Zhao, S., Peoples, M., Tieu, T.N., Warmoes, M.O., Lorenzi, P.L., Muller, F.L., DePinho, R.A., Draetta, G.F., Toniatti, C., Jones, P., Heffernan, T.P., Marszalek, J.R.
Cell Rep