1 keywords

CATH Domain 5ulvA02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.110 L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
Homologous Superfamily 3.90.110.10 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal

Domain Context

CATH Clusters

Superfamily Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family Malate dehydrogenase

Enzyme Information

1.1.1.37
Malate dehydrogenase.
based on mapping to UniProt Q84FY8
(S)-malate + NAD(+) = oxaloacetate + NADH.
-!- Also oxidizes some other 2-hydroxydicarboxylic acids.

UniProtKB Entries (1)

Q84FY8
MDH_METEA
Methylorubrum extorquens AM1
Malate dehydrogenase

PDB Structure

PDB 5ULV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Conformational changes on substrate binding revealed by structures of Methylobacterium extorquens malate dehydrogenase.
Gonzalez, J.M., Marti-Arbona, R., Chen, J.C.H., Broom-Peltz, B., Unkefer, C.J.
Acta Crystallogr F Struct Biol Commun