CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.40 | 3-Layer(aba) Sandwich |
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3.40.430 | Dihydrofolate Reductase, subunit A |
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3.40.430.10 | Dihydrofolate Reductase, subunit A |
Domain Context
CATH Clusters
Superfamily | Dihydrofolate Reductase, subunit A |
Functional Family | Dihydrofolate reductase |
Enzyme Information
1.5.1.3 |
Dihydrofolate reductase.
based on mapping to UniProt P0ABQ4
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.
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UniProtKB Entries (1)
P0ABQ4 |
DYR_ECOLI
Escherichia coli K-12
Dihydrofolate reductase
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PDB Structure
PDB | 5UIH |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
A Structural Basis for Biguanide Activity.
Biochemistry
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