CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family | N-terminal Xaa-Pro-Lys N-methyltransferase 1 |
Enzyme Information
| 2.1.1.299 |
Protein N-terminal monomethyltransferase.
based on mapping to UniProt Q5VVY1
S-adenosyl-L-methionine + N-terminal-(A,P,S)PK-[protein] = S-adenosyl-L- homocysteine + N-terminal-N-methyl-N-(A,P,S)PK-[protein].
-!- This enzyme methylates the N-terminus of target proteins containing the N-terminal motif (Ala/Pro/Ser)-Pro-Lys after the initiator L-methionine is cleaved. -!- In contrast to EC 2.1.1.244, the protein only adds one methyl group to the N-terminal.
|
UniProtKB Entries (1)
| Q5VVY1 |
NTM1B_HUMAN
Homo sapiens
Alpha N-terminal protein methyltransferase 1B
|
PDB Structure
| PDB | 5UBB |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2.
Commun Biol
|