CATH Domain 5tx6B00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.10	Ribbon
	2.10.90	Cystine Knot Cytokines, subunit B
	2.10.90.10	Cystine-knot cytokines

Domain Context

CATH Clusters

Superfamily	Cystine-knot cytokines
Functional Family

Enzyme Information

UniProtKB Entries (1)

TGFB2_MOUSE

Mus musculus

Transforming growth factor beta-2 proprotein

PDB Structure

PDB	5TX6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	An engineered transforming growth factor beta (TGF-beta ) monomer that functions as a dominant negative to block TGF-beta signaling. Kim, S.K., Barron, L., Hinck, C.S., Petrunak, E.M., Cano, K.E., Thangirala, A., Iskra, B., Brothers, M., Vonberg, M., Leal, B., Richter, B., Kodali, R., Taylor, A.B., Du, S., Barnes, C.O., Sulea, T., Calero, G., Hart, P.J., Hart, M.J., Demeler, B., Hinck, A.P. J. Biol. Chem.